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The Natural Sciences Research Unit is envisioned as an outstanding research center in the Cordilleras committed to the formation of responsible research-oriented faculty and students, who develop interest to undertake researches in the field of the natural sciences which are directed towards the assessment and use of indigenous materials, flora and fauna of the Cordilleras , while promoting their conservation and protection.
Through the Philippine Institutional University Cooperation Program, the Natural Sciences Research Unit was established in June 1999 becoming the pilot college research center in Saint Louis University.